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Our Mission

To revolutionize the diagnostic, prognostic, and predictive treatment of disease by enabling next generation technologies for non-destructively processing and digitally analyzing tissue in 3D.

Karl Deisseroth, MD, PhD Founder & Scientific Advisor

Over a period of twelve years, his laboratory created and developed optogenetics, hydrogel-tissue chemistry (beginning with CLARITY), and a broad range of supportive and enabling methods. He also has employed his technologies to discover the neural cell types and connections that cause adaptive and maladaptive behaviors, and has disseminated the technologies to thousands of laboratories around the world.

Karl Deisseroth, MD, PhD

Founder & Scientific Advisor

Karl Deisseroth is the D.H. Chen Professor of Bioengineering and of Psychiatry and Behavioral Sciences at Stanford University, and Investigator of the Howard Hughes Medical Institute. He received his undergraduate degree from Harvard, his PhD from Stanford, and his MD from Stanford; he also completed postdoctoral training, medical internship, and adult psychiatry residency at Stanford, and he is board-certified by the American Board of Psychiatry and Neurology. He continues as a practicing psychiatrist at Stanford with specialization in affective disorders and autism-spectrum disease, employing medications along with neural stimulation.

For his discoveries, Deisseroth has received the NIH Director's Pioneer Award (2005), the Zuelch Prize (2012), the PerlPrize (2012), the BRAIN prize (2013), the Pasarow Prize (2013), the Breakthrough Prize (2015) the BBVA Award (2016), the Massry Prize (2016) and the Harvey Prize from the Technion/Israel (2017), and among other honors, was the sole recipient for optogenetics of the 2010 Koetser Prize, the 2010 Nakasone Prize, the 2011 Alden Spencer Prize, the 2013 Richard Lounsbery Prize, the 2014 Dickson Prize in Science, the 2015 Keio Prize, the 2015 Lurie Prize, the 2015 Albany Prize, the 2015 Dickson Prize in Medicine, the 2017 Redelsheimer Prize, the 2017 Fresenius Prize, the 2017 NOMIS Distinguished Scientist Award, the 2018 Eisenberg Prize, and the 2018 Kyoto Prize. He was selected a Howard Hughes Medical Institute Investigator in 2013, and was elected to the US National Academy of Medicine in 2010 and to the US National Academy of Sciences in 2012.

ClearLight Biotechnologies has signed an exclusive worldwide licensing agreement to develop and commercialize Crystal, a three-dimensional (3-D) tissue-clearing technology.

Study Shows Promise for Revolutionizing Spatial Tumor Analysis.

Imagine

Non-destructive tissue processing and digital spatial image analysis in 3D to facilitate your pre-clinical and clinical research studies

A way to illuminate your tissue microenvironment in a 3D volume

Automating this process and integrating it into your normal tissue processing work flow

ClearLight Biotechnologies’ automated instrumentation platform study is featured as the 4th news story in Clinical Lab Products’ Prime email newsletter and on Clinical Lab Products’ magazine.

ClearLight Biotechnologies and Researchers at the Indiana University’s Melvin and Bren Simon Cancer Center
Announce publication in Scientific Reports-Nature

ClearLight Biotechnologies (formerly ClearLight Diagnostics, LLC) was founded in 2015 by Karl Deisseroth MD, PhD, the inventor of CLARITY, Optogenetics, and STARmap technologies. It is an early stage company focused on developing automated instrumentation and associated reagents to simplify and expedite non-destructive 3D tissue analysis to facilitate preclinical and clinical research applications. The platform will enable an end-to-end solution for 3D analysis of preclinical and clinical models of disease.

Sharla White, PhD presented poster #4690 at AACR Annual Meeting 2019, Atlanta.

Nature posted a video to YouTube describing the CLARITY 3D tissue imaging technology.

View on YouTube

4 Major Platform Components

Multi-sample 3D Tissue Processor
Multi-color/ sample 3D Imaging
Custom 3D Image Analysis Software
Development of Key Biomarker Panels

Focus

Could be applied to any application that relies
on 2D thin section FFPE analysis

Applications

Near Term

Research Use Only (RUO) Service Model
and Limited Beta instruments in field

Preclinical/clinical drug development, exploratory technology inclusion in clinical trials

Future

RUO instrument in field, Companion Diagnostics, LDT (ClearLight Biotechnologies has exclusive rights to diagnostic, prognostic, predictive applications)

Extensive External Network Support

Analysis can be performed for select biomarkers, please contact us to find out if your target of interest is one of them. Imaging is currently performed on select fields of view instead of the entire sample.

Submission Guidelines

Tissue Sample Requirements: