ClearLight Biotechnologies
See More Biology
The Next Dimension in Tissue Analysis
Services
ClearLight Biotechnologies provides tissue processing, imaging and analysis services to pharmaceutical, biotechnology and academic researchers.
CLARITY Tissue Clearing
CLARITY EXPERTS
CLARITY Infographic
Free Download
Immunohistochemistry
IHC in 3D
Optimized Antibodies
Antibodies for CLARITY
3D Image Analysis in 3D
2D FFPE vs 3D CLARITY
Contract Research
Your R&D Resource
Products
ClearLight offers reagents so researchers can try the CLARITY tissue clearing method for themselves. We include High Lipid and Low Lipid kits as well as an optional immunostaining buffer.
Cancer Doesn’t Limit Itself to 2 Dimensions. Neither Should We.
Collaborate
We are building something special. We invite you to coordinate with our scientific staff. Talk to a member of our science team about research alignment. See how Tru3D custom services can help your organization achieve its research objectives.
Imagine, non-destructive tissue processing to facilitate your pre-clinical and clinical research studies.
Publications
ClearLight Biotechnologies is a contract research partner who can provide expert CLARITY tissue clearing, immunohistochemistry, and 3D imaging so researchers and scientists can see more biology.
- Three-dimensional imaging and quantitative analysis in CLARITY processed breast cancer tissues
Nature: Scientific Reports, (2019) Chen Y, Shen Q, White SL, Gokmen-Polar Y, Badve S, & Goodman LJ. 9:5624. - Three-dimensional intact-tissue sequencing of single-cell transcriptional states
Science. 2018 Jul 27;361(6400) Wang X, Allen WE, Wright MA, Sylwestrak EL, Samusik N, Vesuna S, Evans K, Liu C, Ramakrishnan C, Liu J, Nolan GP, Bava FA, Deisseroth K. - Hydrogel-tissue chemistry: principles and applications
Gradinaru V, Treweek J, Overton K, Deisseroth K. Annual Review of Biophysics, 2018 May 20;47:355-376. - Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease
Hsueh B, Burns VM, Pauerstein P, Holzem K, Ye L, Engberg K, Wang A-C, Gu X, Chakravarthy H, Arda HE, Charville G, Vogel H, E mov IR, Kim S, Deisseroth K. Sci Rep. 2017 Jul 19;7(1):5899. - A look inside the brain
Deisseroth K. Scientific American, 2016 Sep 20;315(4):30-37 - Multiplexed intact-tissue transcriptional analysis at cellular resolution
Sylwestrak EL, Rajasethupathy P, Wright MA, Jaffe A, Deisseroth K. Cell. 2016 Feb 11;164(4):792-804 - CLARITY for mapping the nervous system
Chung K, Deisseroth K. Nature Methods. June 2013. 10(6):508-13. - Structural and molecular interrogation of intact biological systems
Chung K, Wallace J, Kim SY, Kalyanasundaram S, Andalman AS, Davidson TJ, Mirzabekov JJ, Zalocusky KA, Mattis J, Denisin AJ, Pak S, Bernstein H, Ramakrishnan C, Grosenick L, Gradinaru V, and K Deisseroth. Nature 497, 332–337 (16 May 2013).
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ClearLight for ImmunoOncology Research
Preclinical immuno-oncology researchers can find more information about ClearLight’s Lab Services. We discuss the CLARITY Tissue Clearing process and how we use it to capture stunning images of the microenvironment in actual 3D. -
Introduction to ClearLight Biotechnologies Services
Welcome to the ClearLight Biotechnologies YouTube Channel. This video is an introduction to our services.
For more detail about our services please visit the ClearLight Biotechnologies Services page.
https://clearlightbiotechnologies.com/services/
On the services page you will also find:
Antibodies Download
CLARITY Infographic
Tru3D Download
ClearLight Biotechnologies Company Fact Sheet
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Other Videos to check out this YouTube Channel:
CLARITY 101 - https://youtu.be/q4JfjAoe4aQ
3D IHC - https://youtu.be/DoZ-JFgIB3U
3D Imaging - https://youtu.be/eyqnUo1UfJM
Why do 3D over 2D? - https://youtu.be/LYO0nK-MtoQ
If you found this video helpful, please subscribe to this channel and click the notification bell to receive email notification as
new videos are published.
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Still have questions?
If you still have questions about our services please visit our website. We are happy to receive your call, email, or answer your questions in online chat.
https://clearlightbiotechnologies.com/contact
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Connect:
Follow us on social media, signup for the Creating Cures Community Newsletter, and join the conversation.
https://clearlightbiotechnologies.com/connect/ -
3D Imaging
If you find this video helpful, please subscribe to this channel and click the notification bell to receive email notification as new videos are published.
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3D Imaging
When researchers can view spatial relationships in X, Y, and Z dimensions the understanding of the tissue microenvironment can spark new discoveries. This is the capability we are developing at ClearLight Biotechnologies. Our Tissue Analysis begins with CLARITY Tissue Clearing followed by multiplexed immmunohistochemistry. The stained tissued is then placed in a refractive index matching mounting solution for imaging with a confocal or light sheet microscope or another imaging platform.
Researchers employ multiplex IHC staining to identify cell phenotypes of interest within the tissue microenvironment. Since the sample is embedded and intact within the hydrogel matrix the same tissue has the potential to be imaged entirely in three dimensions.
The tissue's transparency enables 3D imaging of subcellular components such as DNA, RNA, and proteins for analysis within the tumor microenvironment of a tissue.
For additional images and comparison to other protocols visit our Tissue Clearing Comparison page.
https://clearlightbiotechnologies.com/tissue-clearing-comparison/?utm_source=YouTube&utm_medium=video&utm_campaign=3DImaging
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For additional information or to download the CLARITY Tissue Clearing Infographic visit the links below:
Learn More About CLARITY Tissue Clearing
https://clearlightbiotechnologies.com/clarity-tissue-clearing/?utm_source=YouTube&utm_medium=video&utm_campaign=3DImaging
Download the CLARITY Tissue Clearing Infographic
https://clearlightbiotechnologies.com/clarity-tissue-clearing-infographic/?utm_source=YouTube&utm_medium=video&utm_campaign=3DImaging
Learn More About ClearLight Biotechnologies
https://clearlightbiotechnologies.com/?utm_source=YouTube&utm_medium=video&utm_campaign=3DImaging
For more detail about our services please visit the ClearLight Biotechnologies Services page.
https://clearlightbiotechnologies.com/services/?utm_source=YouTube&utm_medium=video&utm_campaign=3DImaging
On the services page you will also find:
Antibodies Download
CLARITY Infographic
Tru3D Download
ClearLight Biotechnologies Company Fact Sheet
----------
Other Videos to check out this YouTube Channel:
CLARITY 101 - https://youtu.be/q4JfjAoe4aQ
3D IHC - https://youtu.be/DoZ-JFgIB3U
3D Imaging - https://youtu.be/eyqnUo1UfJM
Why do 3D over 2D? - https://youtu.be/LYO0nK-MtoQ
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Still have questions?
If you still have questions about our services please visit our website. We are happy to receive your call, email, or answer your questions in online chat.
https://clearlightbiotechnologies.com/contact/?utm_source=YouTube&utm_medium=video&utm_campaign=3DImaging
----------
Connect:
Follow us on social media, signup for the Creating Cures Community Newsletter, and join the conversation.
https://clearlightbiotechnologies.com/connect/?utm_source=YouTube&utm_medium=video&utm_campaign=3DImaging
Events & News
ClearLight Biotechnologies news and announcements. Collaborations, Trade Shows and Events, Company News, and more.
Nature.com Scientific Reports awards ClearLight for publishing the Top 100 Scientific Reports cancer papers in 2019.
ClearLight was a sponsor at Immuno-Oncology 360°. Watch Dr. Sharla White’s Quick Fire Presentation on Solutions that Support Immuno-Oncology R&D.
Our lab services are up and running (although at a reduced capacity to keep employees safe). We stand ready to serve.
See More. Explore Further.
Creating Cures Community
We applaud the research community and their involvement in the drug discovery and development process. These are the modern heroes who will create the cures of tomorrow for the diseases that impact human potential and decrease lifespan. Perhaps you are one. Join us.