ClearLight Biotechnologies

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The Next Dimension in Tissue Analysis

AACR 2021

ClearLight Supporting Preclinical Cancer Researchers - AACR 2021. Learn More.

Services

ClearLight Biotechnologies provides tissue processing, imaging and analysis services to pharmaceutical, biotechnology and academic researchers.

CLARITY Tissue Clearing

Cleared Tissue Sample from ClearLight Bio
CLARITY EXPERTS

CLARITY Infographic

Free Download
Free Download

Immunohistochemistry

Human Lung Carcinoma: CLARITY Tissue Cleared - Immunostained - Imaged - DAPI (blue), pan-cadherin (green), CD8 (yellow), α-SMA (red)
IHC in 3D

Optimized Antibodies

Antibodies for CLARITY
Antibodies for CLARITY

3D Image Analysis in 3D

Biomarker co-localization and individual cell type classification
2D FFPE vs 3D CLARITY

Contract Research

Your R&D Resource
Your R&D Resource

Products

ClearLight offers reagents so researchers can try the CLARITY tissue clearing method for themselves. We include High Lipid and Low Lipid kits as well as an optional immunostaining buffer.

High Lipid Kit
High Lipid Kit
Low Lipid Kit
Low Lipid Kit
Optimized Reagent for Immunostaining used with CLARITY Tissue Clearing Kit
Immuno-staining Buffer

Cancer Doesn’t Limit Itself to 2 Dimensions. Neither Should We.

Collaborate

We are building something special. We invite you to coordinate with our scientific staff. Talk to a member of our science team about research alignment. See how Tru3D custom services can help your organization achieve its research objectives.

Imagine, non-destructive tissue processing to facilitate your pre-clinical and clinical research studies.

Imagine, a way to illuminate your tissue microenvironment in a 3D volume

Imagine, automating this process and integrating it into your normal tissue processing workflow.

Publications

ClearLight Biotechnologies is a contract research partner who can provide expert CLARITY tissue clearing, immunohistochemistry, and 3D imaging so researchers and scientists can see more biology.

  1. Three-dimensional imaging and quantitative analysis in CLARITY processed breast cancer tissues
    Nature: Scientific Reports, (2019) Chen Y, Shen Q, White SL, Gokmen-Polar Y, Badve S, & Goodman LJ. 9:5624.
  2. Three-dimensional intact-tissue sequencing of single-cell transcriptional states
    Science. 2018 Jul 27;361(6400) Wang X, Allen WE, Wright MA, Sylwestrak EL, Samusik N, Vesuna S, Evans K, Liu C,   Ramakrishnan C, Liu J, Nolan GP, Bava FA, Deisseroth K.
  3. Hydrogel-tissue chemistry: principles and applications
    Gradinaru V, Treweek J, Overton K, Deisseroth K.  Annual Review of Biophysics, 2018 May 20;47:355-376.
  4. Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease
    Hsueh B, Burns VM, Pauerstein P, Holzem K, Ye L, Engberg K, Wang A-C, Gu X, Chakravarthy H, Arda HE, Charville G, Vogel H, E mov IR, Kim S, Deisseroth K. Sci Rep. 2017 Jul 19;7(1):5899.
  5. A look inside the brain
    Deisseroth K.  Scientific American, 2016 Sep 20;315(4):30-37
  6. Multiplexed intact-tissue transcriptional analysis at cellular resolution
    Sylwestrak EL, Rajasethupathy P, Wright MA, Jaffe A, Deisseroth K. Cell. 2016 Feb 11;164(4):792-804
  7. CLARITY for mapping the nervous system
    Chung K, Deisseroth K. Nature Methods. June 2013. 10(6):508-13.
  8. Structural and molecular interrogation of intact biological systems
    Chung K, Wallace J, Kim SY, Kalyanasundaram S, Andalman AS, Davidson TJ, Mirzabekov JJ, Zalocusky KA, Mattis J, Denisin AJ, Pak S, Bernstein H, Ramakrishnan C, Grosenick L, Gradinaru V, and K Deisseroth. Nature 497, 332–337 (16 May 2013).

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Events & News

ClearLight Biotechnologies news and announcements. Collaborations, Trade Shows and Events, Company News, and more.

Nature.com Scientific Reports awards ClearLight for publishing the Top 100 Scientific Reports cancer papers in 2019.

ClearLight was a sponsor at Immuno-Oncology 360°. Watch Dr. Sharla White’s Quick Fire Presentation on Solutions that Support Immuno-Oncology R&D.

Our lab services are up and running (although at a reduced capacity to keep employees safe). We stand ready to serve.

See More. Explore Further.

Creating Cures Community

We applaud the research community and their involvement in the drug discovery and development process. These are the modern heroes who will create the cures of tomorrow for the diseases that impact human potential and decrease lifespan. Perhaps you are one. Join us.

Previous Issues

Analysis can be performed for select biomarkers, please contact us to find out if your target of interest is one of them. Imaging is currently performed on select fields of view instead of the entire sample.

Submission Guidelines

Tissue Sample Requirements: