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Tissue Clearing Applications

Skin Tissue

Tissue Clearing Skin Using CLARITY Protocol

ClearLight scientists have worked with human and mouse skin. Forum comments and publications have mentioned that the CLARITY method isn’t suitable for skin. This is a fundamental misunderstanding of the protocol and optimizing it for different tissue clearing applications. Because skin contains a high amount of extracellular matrix in the connective tissue, it will not appear as optically transparent to the naked eye as compared to lipid rich tissues such as the brain. After immunostaining and RI-matching imaging skin tissue reveals distinct channels with enough strength and precision to present meaningful scientific results.

Try tissue clearing on your own.

If you want to apply CLARITY to the tissues highlighted on this page, you will need to use the ClearLight LOW Lipid Tissue Clearing Kit.

 Collaborative Research Organization for Tissue Clearing Tonsil and Tru3D Tissue Analysis

Leverage our Internal R & D

When you work with us you gain the benefit of our internal experiments, assessments, and rigorous testing. In addition to performing our lab services: CLARITY Tissue Clearing, 3D IHC, and Tru3D Tissue Analysis, ClearLight scientists perform internal Research and Development to advance our understanding and applications of CLARITY to other tissue types and downstream applications. Researchers who work with us benefit from this exploratory work. The ClearLight “lab basement” is full of failed or pivoted experiments that helped inform our path to arrive at what does work. Work with us to avoid making the same mistakes that we have made or going down the blind alleys that we’ve pivoted away from.

“If you don’t want to spend the time figuring it out, we can help. We work hard to make this look easy.” - Dr. Sharla White, VP of Research and Development

Ready to Discuss Your Research Question? Meet with our Application Scientist.

Analysis can be performed for select biomarkers, please contact us to find out if your target of interest is one of them. Imaging is currently performed on select fields of view instead of the entire sample.

Submission Guidelines

Tissue Sample Requirements: