Tissue Clearing Applications


Human Pancreas
Tissue Clearing

ClearLight has applied CLARITY tissue clearing, immunohistochemistry, and Tru3D image analysis to normal and diseased human pancreata.

Human pancreas tissue clearing using the CLARITY protocol. Pancreatic ductal adenocarcinoma tumor immunostained for 3D imaging. Human PDAC: DAPI (blue), Ki67 (yellow), pan-Cytokeratin (green), CD3 (red)

Human Pancreas Tissue Clearing, Immunostaining, and 3D Imaging

A Stage IIB tumor of an invasive pancreatic ductal adenocarcinoma tumor was immunostained and imaged with DAPI, pan-cytokeratin, Ki-67, and CD3. Pan-CK identified the epithelial cells within the tumor with some Ki-67 co-localization observed in proliferating cells. A few CD3 T cells were also noted within the PDAC tumor.

 Collaborative Research Organization for Tissue Clearing Tonsil and Tru3D Tissue Analysis

Leverage our Internal R & D

When you work with us you gain the benefit of our internal experiments, assessments, and rigorous testing. In addition to performing our lab services: CLARITY Tissue Clearing, 3D IHC, and Tru3D Tissue Analysis, ClearLight scientists perform internal Research and Development to advance our understanding and applications of CLARITY to other tissue types and downstream applications. Researchers who work with us benefit from this exploratory work. The ClearLight “lab basement” is full of failed or pivoted experiments that helped inform our path to arrive at what does work. Work with us to avoid making the same mistakes that we have made or going down the blind alleys that we’ve pivoted away from.

“If you don’t want to spend the time figuring it out, we can help. We work hard to make this look easy.” - Dr. Sharla White, VP of Research and Development

Ready to Discuss Your Research Question? Meet with our Application Scientist.

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Analysis can be performed for select biomarkers, please contact us to find out if your target of interest is one of them. Imaging is currently performed on select fields of view instead of the entire sample.

Submission Guidelines

Tissue Sample Requirements: