ClearLight Services

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ClearLight empowers researchers to see more biology.

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ClearLight Biotechnologies provides tissue processing, imaging and analysis services to pharmaceutical, biotechnology and academic researchers. ClearLight utilizes the patent-protected CLARITY technology, licensed from Stanford University, Palo Alto, CA. The CLARITY technology allows clearing of animal and human tissue so that it can be analyzed with powerful 3D microscopes and AI software (under development). The images and analysis allow researchers to better understand the tissue and tumor microenvironment to facilitate discovery of new methods and drugs to treat disease.

CLARITY Tissue Clearing

Need to know more about CLARITY Tissue Clearing? Visit the CLARITY tissue clearing page to learn the background and specific steps in the ClearLight CLARITY Tissue Clearing Process. Download the CLARITY Tissue Clearing Infographic.

3D IHC

ClearLight offers antibody-based immunostaining or labeling for many nucleic acids (RNA/DNA) to highlight specific structures in the clarified sample. Multiplexed immunofluorescence staining enables advanced Tru3D™ tissue analysis.

TRU 3D™ Tissue Analysis

After tissue clearing, animal and human tissue can be analyzed with powerful 3D microscopes and the company’s proprietary AI software (under development). This allows researchers to better understand the tissue and tumor microenvironment.

Submit Tissue Samples

Tissue Sample Requirements:

Sample Size dimensions:

    • 5 mm dia. x 1 mm thick or
    • 5 x 5 x 1 mm

Acceptable Sample Species:

    • Mouse
    • Human

Acceptable Tissue type:

    • Tumor
      • Syngeneic
      • Xenograft
      • PDX (patient derived xenograft)
      • Primary
    • Kidney
    • Spleen
    • Skin
    • Lung
    • Tonsil
    • Brain
    • Pancreas
    • Liver
    • Mammary
    • Skin
    • Prostate

Submission Guidelines

The submitted sample must be pre-fixed in either

      • 4% paraformaldehyde (PFA) at 4°C or
      • 10% neutral buffered formalin (NBF) at 4°C for 24 hours.
        • Samples prepared with fixatives other than 4% PFA or 10% NBF have not been validated or already determined to interfere with our protocol.

The tissue must be noted:

      • Perfused or not Perfused
      • This is necessary for imaging purposes.

All submitted samples should clearly labeled.

      • A list of all supplied samples is preferred to confirm receipt of all samples.

Samples should be shipped in a sealed container or either PBS or TBS solution.

      • Samples that will be stored for prolonged periods (>1 week) of time prior to shipment should be stored in PBS+NaN3 (0.01%) at 4°C.

Shipped samples should be scheduled for delivery to ClearLight Biotechnologies Monday through Wednesday with a provided tracking number.

      • Please inform ClearLight Biotechnologies of the scheduled delivery and any additional delivery information.

Shipping Samples to ClearLight

  • Samples should be shipped in a sealed container, in either PBS or TBS solution.
  • Please clearly label all samples in your shipment.
  • Please include a detailed list of all the samples in your shipment, so that we can confirm we have received them all.
  • Please inform ClearLight Biotechnologies of the scheduled delivery and any additional delivery information including shipping carrier and tracking number.

Please address your shipment as follows:

ClearLight Biotechnologies
Attn: Sharla White/Lab Services
428 Oakmead Parkway
Sunnyvale, CA 94085

Terms of Service

Terms and conditions apply to your purchase of the tissue clearing and imaging services from ClearLight Biotechnologies, LLC. See Terms of Service.

Shipping Tissue Samples to ClearLight Biotechnologies Services

Contact ClearLight Services

We want to make sure we answer your questions about our services and technologies. We have created FAQs, resources, primers, and other specific pages. Other ways to get help:

  • Type your question into the search box in the upper right hand corner of this web page
  • Message us through our live chat feature. We are happy to assist you!
  • Send us a message through the chat feature or use our contact form in the event we've stepped away (sometimes we need to sleep, too!)
Contact ClearLight Biotechnologies Services

ClearLight Services FAQs

Services

No. ClearLight Biotechnologies provides study-related services to sponsors of drug research programs early in the drug development cycle. Our contract research and development services are for Research Use Only (RUO).

Technology

Staining can be performed on the tissue sample without interference from the hydrogel matrix. With CLARITY tissue clearing, the sample is processed via Multiplex IHC staining, allowing the characteristics of the tumor microenvironment to be fully analyzed in three dimensions.

No, the CLARITY method was originally developed at the Karl Deisseroth Lab at Stanford University Medical Center. Dr. Deisseroth is a founder and scientific advisor to ClearLight Biotechnologies.  However, ClearLight is automating the method so that it can be utilized by researchers and eventually clinicians across the world.

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More ClearLight Services Resources

Award Winning Breast Cancer Study

“Three-dimensional Imaging and Quantitative Analysis in CLARITY Processed Breast Cancer Tissues,” awarded as one of the top 100 downloaded cancer papers.

Tissue Clearing Comparison

Considering CLARITY alongside other tissue clearing protocols? See the head-to-head comparison of tissue clearing protocols, CLARITY, CUBIC, iDISCO, and Visikol.

Contract Research and Development

Bring us your burning question and we'll apply our expertise and provide perspective. Together we'll explore further. With our help your team will See More Biology.

ClearLight Services Downloads

Antibodies Download

CLARITY Infographic

Company Fact Sheet

Creating Cures Community

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Analysis can be performed for select biomarkers, please contact us to find out if your target of interest is one of them. Imaging is currently performed on select fields of view instead of the entire sample.

Submission Guidelines

Tissue Sample Requirements: